The novel bis-benzylisoquinoline PY35 reverses P-glycoprotein-mediated multidrug resistance
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چکیده
منابع مشابه
The novel bis-benzylisoquinoline PY35 reverses P-glycoprotein-mediated multidrug resistance.
Multidrug resistance (MDR) to chemotherapeutic drugs is the main cause of chemotherapy failure in cancer treatment, and it generally results from expression of ATP-dependent efflux pump P-glycoprotein (P-gp). MDR reversal agents typically act by inhibiting the drug efflux activity of P-gp, thereby increasing intracellular drug levels. PY35 is a novel 5-substituted tetrandrine (Tet) derivative (...
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ژورنال
عنوان ژورنال: Oncology Reports
سال: 2014
ISSN: 1021-335X,1791-2431
DOI: 10.3892/or.2014.3326